How Ikris Pharma's Named Patient Program Can Help in Accessing Vital Medications

 In the world of healthcare, getting the right medicine at the right time is crucial, especially for patients with serious illnesses. But sometimes, certain medicines aren't available in our country or haven't been approved yet. That's where Ikris Pharma's Named Patient Program comes in.

Our program is designed to help patients get access to important medications that they urgently need. Even if the medicine isn't approved in India or isn't available in the market, we can still help. Here's how:

Expertise: We have a team of experts who understand the ins and outs of importing medicines and navigating regulatory requirements. This means we can promptly and efficiently get the medicine to the patient who needs it.

Personalized Care: We work closely with healthcare professionals to ensure that each patient receives the right medicine and the proper guidance on how to use it safely and effectively.

Timely Delivery: We understand that time is of the essence when it comes to healthcare. That's why we prioritize timely delivery, so patients can start their treatment as soon as possible.

Compassionate Support: Dealing with a critical illness can be overwhelming. Our team is here to provide compassionate support every step of the way, answering questions and offering guidance to patients and their families.

With Ikris Pharma's Named Patient Program (NPP), patients can rest assured knowing that they have a dedicated partner working to ensure they get the care they need. Because, at Ikris Pharma, we believe that everyone deserves access to life-saving medications, no matter where they are or what their circumstances may be.

Contact Ikris Pharma to Learn More:
If you or someone you know is in need of access to vital medicines through our Named Patient Program, don't hesitate to contact Ikris Pharma today. Our dedicated team is here to answer any questions you may have and provide assistance every step of the way.

Together, we can ensure that patients have access to the medications they need to improve their quality of life (QoL) and fight against challenging medical conditions. Contact us via TOLL-FREE: 1800-889-1064 or Email us at info@ikrispharmanetwork.com to learn more about our Named Patient Program (NPP) and how we can help.

Early Detection and Screening: Saving Lives from Breast Cancer

 At times, breast cancer is found after the occurrence of symptoms, but in many cases, breast cancer has no symptoms. This is why regular screening of breast cancer is extremely important. Screening and early detection of breast cancer play a significant role in individuals' health. Screening tests can be very helpful in the early detection of breast cancer at an early stage when it has not progressed and the probability of survival is highest.

Whether you are prepared to get your first-ever screening mammogram or looking to know more about follow-up tests following an abnormal outcome, learning about screening tests and the need for early detection of breast cancer can help individuals take charge of their health.

Screening of Breast Cancer:

The common tests for breast cancer detection are screening mammograms and clinical breast exams. Screening tests are used to find breast cancer in an individual without warning signs or symptoms. 

What is a screening mammogram? 

It is a test that uses X-rays to take breast images. Nowadays, it's the most promising screening test used to detect breast cancer in most cases. With the help of screening mammograms, breast cancer can be detected early, sometimes up to ten years before it can be found by you or your clinician.

This test takes around 15 minutes. On your screening day, wear a shirt you can take off easily. Do not use perfume, deodorant, powder, or lotion on the breast or under your arms. These products may show up on a mammogram and make it difficult to read.

You may experience some pressure, but getting a mammogram shouldn't hurt. Let your technologist know if you feel discomfort during the test.

When should one get a breast cancer screening test?

• Women at average risk: Such women should talk with a clinician about which screening tests are apt for them. They should have a mammogram each year starting at age 40. They should have a clinical breast exam at least every 3 years, starting by the age of 20 and every year by the age of 40.
• Women at higher risk: Such women should talk with their clinicians about which screening tests are apt for them and when to start screening. They must be screened earlier and more often than all those at average risk.
• Men at higher risk: For men with BRCA1 or BRCA2 inherited gene mutation, there are specific screening recommendations for breast and certain other cancers.
• Transgender people: For transgenders, breast cancer screening recommendations are personalized and differ by age, sex (at birth), personal risk of breast cancer, etc.

About Follow-up Tests:

In most cases, the mammogram results will be good news. It will show no indication of breast cancer. In case of abnormal outcomes, follow-up tests can be considered to check whether or not the finding is breast cancer. Occasionally, cancer of the breast can be ruled out through a follow-up diagnostic mammogram, breast MRI, or breast ultrasound.

• Diagnostic mammogram
• Breast ultrasound 
• Breast MRI
• Biopsy

Conclusion:

The diagnosis of breast cancer is not a death sentence. Self-examination and regular screenings can save lives. Through self-examinations, women may notice the breast skin feels hard, tender, or warm, with peeling, redness, or flaking of the nipple skin. Some may experience skin dimpling or nipple retraction (nipple turning inward). Some women may feel nipple discharge. These symptoms may or may not occur with breast pain. Apart from this, some early signs of breast cancer to look for are changes in breast color, swelling in any breast part or swollen lymph nodes under the arm, itchy/irritated breasts, or changes in breast size/shape.

Reference:

https://www.cancer.org/cancer/types/breast-cancer/screening-tests-and-early-detection.html

https://marathonforbreastcancer.blogspot.com/2023/08/early-detection-and-screening-saving.html

Breaking Stereotypes: Men and Breast Cancer

 Breast cancer is often associated with women, but it's important to recognize that men can be affected by this disease as well. While it's relatively rare in men, breast cancer carries similar risks and potential consequences for both genders. 

Though men account for a small percentage of breast cancer cases, it's crucial not to overlook the importance of awareness, early detection, and understanding the unique challenges they may face. Men need to be made aware of the potential early indications and symptoms of breast cancer, which include a lump in the breast tissue, changes to the nipple, or dimpling of the skin.

 Any unusual changes should be promptly reported to a healthcare professional for evaluation.

The associated risk factors for breast cancer in men are somewhat different than those in women. Family history, genetic mutations, radiation exposure, and certain hormonal treatments are some of the known risk factors. Being aware of these factors can help men take proactive measures to reduce their risk, such as undergoing regular screenings and adopting a healthy lifestyle.

One of the challenges men with breast cancer face is the lack of awareness and stigma surrounding the disease. Many men might not suspect breast cancer when they experience symptoms, leading to delays in diagnosis and treatment. Increasing awareness about male breast cancer can help overcome this barrier and encourage men to seek medical attention without hesitation.

Male breast cancer treatment choices are comparable to those for female breast cancer patients and may include surgery, radiation, chemotherapy, and hormone therapy. 

 The treatment approach depends on the stage of the cancer and individual health factors.

In India, raising awareness about male breast cancer is particularly important due to prevailing gender norms and limited understanding. Educational campaigns, support groups, and initiatives by healthcare organizations can contribute to breaking down barriers and dispelling myths.

In conclusion, breast cancer is not exclusive to women, and men can be affected by it too. Creating awareness, promoting early detection, and offering support are vital steps in ensuring that men with breast cancer receive timely and effective care. By acknowledging that breast cancer can impact anyone, regardless of gender, we can take significant strides in combating this disease.Joining hands in spreading awareness,Ikris Pharma Network has announced the highly anticipated "Ikris Run," This event will symbolize unity and determination, bringing together participants from diverse backgrounds to contribute to an essential cause.

Breast cancer is still a serious problem that affects many people all over the world. Ikris Pharma Network has adopted an upbeat position in raising awareness of breast cancer and encouraging action since it recognizes the necessity of tackling this issue.

References:

• https://thepharmatimes.in/ikris-pharma-takes-strides-against-breast-cancer-with-the-inspiring-ikris-run-uniting-communities-for-awareness-and-action/
• https://core.ac.uk/download/pdf/81110159.pdf

What is Darunavir? Price, Availability, And Generic Supplier

 FDA Approved: Yes (First approved June 23, 2006)

Generic Brand: Daruvir

Generic Name: Darunavir

Dosage form: Tablets

Previous Name: TMC114

Approved for: HIV Infection

Company: Janssen Pharma, Inc.

Darunavir Overview:

Darunavir is supplied under the generic brand name Daruvir. This prescription medication is approved by the FDA for the treatment of HIV infection in adults and children aged 3 years and older. The medication Darunavir is always used in conjunction with another HIV medicine ritonavir and other medicines.

Darunavir falls under the class of HIV medicines named protease inhibitors (PIs). These PIs inhibit an HIV enzyme known as protease. By inhibiting protease, PIs help in preventing HIV from multiplying and can scale down the aggregation of HIV in the body.

Taking a combination of HIV drugs (known as an HIV treatment regimen) every day helps individuals with HIV live longer, quality of life. These medicines also scale down the probability of HIV transmission.

Darunavir Dosage Form:

Darunavir is a HIV-1 (human immunodeficiency virus) protease inhibitor. The FDA-approved dosage form of this medicine is 75 mg tablets, 150 mg tablets, 600 mg tablets, 800 mg tablets, and 100 mg/mL oral suspension (an oral suspension is a mixture of a drug and a liquid that can be taken orally).

Take darunavir as per your health specialist's instructions. Take darunavir along with ritonavir constantly with food. If your child is prescribed this medicine, follow the words for using the medicine given to you by your health specialist. Always take darunavir together with the HIV medicine ritonavir and other HIV medicines.

Where to Buy Darunavir Tablets:

Darunavir 75 mg, 150 mg, 600 mg, and 800 mg tablets are prescription medications, doctor-prescribed pharmaceutical medicines that can be legally dispensed against a valid prescription only. Buy Darunavir tablets online from India at reasonable prices. This generic medicine tends to cost less than its existing brand-name alternatives.

Darunavir can be made available in India, Africa, Brazil, Australia, Bangladesh, UAE, Saudi Arabia, the USA, the UK, New Zealand, and other countries across the world. We are certified by Good Distribution Practices (GDP), which demonstrates our involvement and commitment to top-notch quality.

Generic Darunavir Supplier in India:

For darunavir price in India and abroad, kindly dial our TOLL-FREE: 1800-889-1064, or Call/WhatsApp: +91 8130290915. One can order darunavir if the medicine has not been approved or is not available in your home country. We have made our mark in the industry by offering genuine, reasonable, and best quality delivery of FDA-approved medications for HIV/AIDS.

Our high-quality service, huge experience, market credentials, on-time or before-time delivery, and tie-ups and sourcing from the most reliable brands help enable us to offer the best darunavir price from India.

Reference:

https://www.janssencarepath.com/hcp/prezista

Foscarnet Sodium: All you need to know

Foscavir (Foscarnet Sodium) is an organic analogue of inorganic pyrophosphate that inhibits the replication of herpes viruses in vitro, including cytomegalovirus (CMV) and herpes simplex virus types 1 and 2 (HSV1 and HSV-2). Healthcare professionals recommend using this drug in treating patients with CMV (Cytomegalovirus) retinitis in those with acquired immunodeficiency syndrome (AIDS) and acyclovir-resistant herpes simplex virus (HSV) infections in immunocompromised patients. 

Warning and Precautions

 

• Contact of the drug with eyes and skin may be responsible for causing a burning sensation and local irritation. In case of accidental contact, the exposed area must be rinsed immediately with the help of cold water.

•  Healthcare professionals do not recommend Foscarnet injection for use in those patients who are undergoing haemodialysis as dosage guidelines have not been established.

•  One should use foscarnet with caution in those with reduced renal function. Since renal function impairment might occur during foscarnet uses, one should monitor serum creatinine every second day during induction therapy and once a week during maintenance treatment. 

•  To scale down the risk of renal function impairment, one should maintain adequate hydration in all patients. The renal function of those with renal disease or taking concomitant treatment with other nephrotoxic medicines should be closely assessed. 

•  Due to the existence of sodium in the Foscarnet drug, one should avoid its use when a saline load is difficult to be tolerated. All the respective patients should also consider this on a controlled sodium diet. 

•  One should take specific caution with reduced calcium levels before treatment and those with other drugs known to influence serum calcium levels. Electrolytes, mainly magnesium and calcium, should be evaluated prior to and during Foscarnet Sodium injection, 24mg/mL in 250 mL therapy and deficiencies corrected.

•  One should monitor patients precisely with any known existing prolongation of cardiac conduction intervals, mainly QTc, in those with electrolyte disturbances, or bradycardia, as well as those with underlying cardiac diseases due to increased probability of ventricular arrhythmia. 

•  Seizures related to alterations in plasma minerals and electrolytes have been linked with foscarnet treatment. Status epilepticus may occur. Therefore, one should carefully monitor patients for such changes and their potential sequelae. Mineral and electrolyte supplementation can be used.

• The medicine Foscarnet might be excreted in high concentrations in the urine and might be responsible for genital irritation and ulceration. Precisely attention to personal hygiene is required to prevent irritation and ulceration, and cleaning of the genital area after each micturition is required. 

•  Since no clinical experience or investigational findings are available, Forscanet Sodium 24mg/mL in 250 mL should not be prescribed to pregnant women or to women who are lactating.

•  Women capable of childbearing must use appropriate and effective contraception methods during Foscarnet Sodium therapy. Men treated with this medicine should not have a child for 6 months after treatment.

Side-effects

There are several side-effects of Foscarnet Sodium are:

• Fever

•  Flu-like symptoms

•  Chest pain

•  Headache

•  Back pain

•  Vomiting

•  Nausea

•  Diarrhoea

Future of contract manufacturing in Pharmaceutical

 India has a strong presence in the pharmaceutical industry’s CDMO (contract development and manufacturing organization) segment. Since India offers world-class quality pharma products at a low price, contract manufacturing is among the fastest expanding areas of the pharmaceutical business. Contract manufacturing for pharmaceuticals requires innovative technologies to keep up with changing market trends. Today, the emphasis is on building resilience in supply chains with multiple facilities across locations to meet the rising and unprecedented demand. According to MarketsandMarkets, the worldwide pharmaceutical contract development and manufacturing market is expected to grow at a CAGR of 7.7%, from USD 100.7 billion in 2020 to USD 146.1 billion in 2025.

The ever-expanding demand for generics increased pharmaceutical R&D spending, and CDMO investments in sophisticated production methods are some of the factors driving the growth of CDMOs today.  

As a contract development and manufacturing organization (CDMO) supporting key players in the pharmaceutical industry, Ikris Pharma Network (IPN) has prepared for the future by implementing this guidance. Our new multi-product, large-scale fill/finish facility was designed from the ground up with safety, quality, and flexibility top of our minds. By investing in best-in-class equipment supported by the latest technology and designing a facility with superior environmental, health and safety, engineering, and cross-contamination controls, Ikris can support the varied needs of current and prospective clients now and in the future.

As the entire pharmaceutical manufacturing industry continues to shoulder immense pressure to be more cost-effective and reduce timelines for life-saving medicines, dynamic multi-product facilities, and equipment design will only grow in prominence. Flexible equipment supported by modern facility design, along with proven processes and controls, reduce risk and can ultimately help eliminate the threat of cross-contamination. With demand growing daily, pharmaceutical companies should take decisive action today to better prepare for tomorrow by investing significant capital in facility and equipment design modernization.

Trifluridine Tipiracil: A New Oral Therapy Approved for Patients with Metastatic Colorectal Cancer

Fast Facts: 

• Colon and rectal cancers combined are the 3'rd most commonly occurred cancers in men and women.
• Around 1 in 20 Americans will be diagnosed with colon cancer or rectal cancer in his/her lifetime.

What is Trifluridine Tipiracil?

Trifluridine Tipiracil tablets are a prescription medication for refractory Metastatic Colorectal Cancer. It is supplied as an oral tablet, which means it is administered by mouth. This medicinal product is a prescription chemotherapy tablet that is made up of two parts. This therapy offers you a chance to continue treating your cancer. It may help you live longer and resist or inhibit the progression of your cancer for a period of time.

The medication trifluridine tipiracil was evaluated in a clinical trial of 800 populations. 

• Half of the populations treated with trifluridine tipiracil therapy were still alive at 7.1 months and half of the populations who received placebo were still alive at 5.3 months 
• Worsening of the condition or death occurred in 88% of patients treated with trifluridine tipiracil and 94% of patients who received placebo

The trifluridine tipiracil tablet comes in 2 strengths: 15mg and 20mg. A health specialist may prescribe both strengths for your prescribed dose.

Who is Trifluridine Tipiracil For:

This medicinal product is recommended for treating those with colon or rectal cancer that has spread to other portions of the body and who have earlier treated with or cannot take certain chemotherapy agents. Those previous agents may include

• Anti-VEGF biological therapy, or VEGF inhibitors: Such as bevacizumab or Aflibercept. 
• Anti-EGFR therapy, or EGFR inhibitors (if you have the KRAS wild type gene): Such as cetuximab; or panitumumab. 
• Fluoropyrimidine: Such as 5-FU, also known qs 5-fluorouracil.
• Oxaliplatin-based treatment: Such as 5-FU, leucovorin, and oxaliplatin; capecitabine and oxaliplatin; or oxaliplatin. 
• Irinotecan-based treatment: Such as 5-FU, leucovorin, and irinotecan; capecitabine and irinotecan; or irinotecan. 

In case you aren’t sure what treatments you’ve had in the past, ask your health specialist. 

Mechanism of Action of Trifluridine Tipiracil

Tablets of trifluridine tipiracil work in a different way than other therapies for colon or rectal cancer. That is why it may still help individuals for whom other therapies have stopped working. This medicinal product is the first FDA-approved combination tablet for the treatment of patients with refractory Metastatic Colorectal Cancer. It is an oral chemotherapy that is two medications in one. With the two medicines working together, trifluridine and tipiracil may help inhibit cancer cell growth. 

How can Trifluridine Tipiracil Help Me

Trifluridine Tipiracil has been proven to allow some individuals with refractory Metastatic Colorectal Cancer to live longer. It has also been proven to slow or stop the growth of disease for a period of time. Like all medicines approved by the FDA, trifluridine tipiracil 20 mg/8.19mg was evaluated in clinical trials. The clinical trial in which this medicine was studied included 800 populations.

Some individuals in the trial lived longer than others. It is hard to predict exactly how much this agent may help extend a particular individual’s life, because everyone is different.

Most Important Information About Trifluridine Tipiracil

A respective healthcare specialist should assess blood cell counts prior to treatment with trifluridine and tipiracil pills, at day 15 of each treatment cycle, and as required.

• Reduced blood counts are common with therapy and can sometimes be severe and life-threatening. Therapy can be responsible for causing a reduction in WBCs, RBCs, and platelets. Reduced WBCs can make you more likely to get severe infections that might lead to death. A health specialist may decrease or stop the dose if you have low WBC or low platelet counts. 
• Inform your health specialist promptly in case you develop any signs/symptoms of infection such as fever, chills, or body aches. 

Most common side effects due to Trifluridine Tipiracil: Almost all patients treated with trifluridine tipiracil 15mg/6.14mg experience side effects at some time. Some commonly reported side effects you may experience include:

• Vomiting
• Diarrhea
• Abdominal pain
• Fever
• Tiredness
• Nausea
• Decreased appetite

Inform your health specialist in case you have nausea, vomiting, or diarrhea that is severe or persistent. Note that, these are not all of the possible side effects of this medicinal product.

Serious side effects due to Trifluridine Tipiracil: This drug may also be responsible for causing serious side effects, including:

Low blood counts: Low blood counts are a bit common with Trifluridine Tipiracil treatment and can sometimes be severe and life-threatening. The medication can cause a reduction in white blood cells (WBCs), red blood cells (RBCs), and platelets. Low white blood cells (WBCs) can make you more prone to catch serious infections that could lead to death. A health specialist should do blood tests prior to Trifluridine Tipiracil therapy, at day 15 during therapy with this medicine, and as needed to assess the blood cell counts. A health specialist may reduce your dose of Trifluridine Tipiracil or stop it in case you have low white blood cell (WBCs) or platelet counts.

Note: Let your health specialist know right away in case you get any of the following signs/symptoms of infection throughout your treatment with Trifluridine Tipiracil: chills, body aches, or fever.

How to Take Trifluridine Tipiracil?

Proposed dosage of trifluridine and tipiracil pills are taken twice a day, after you eat breakfast and dinner (promptly after or up to 1 hour after). The type of food typically does not matter. Your trifluridine and tipiracil dose is determined on behalf of your body surface area (BSA). This depends on the height and weight. The higher your body surface area, the higher your dose will be. In case you have any query regarding BSA or dose, ask your health specialist. 

Supplied in 2 strengths: 15-mg and 20-mg tablets, take your dosage after morning and evening meals for 5 days a week, and then rest for a couple of days. This goes on for two weeks. Then you will not take this medicine for two weeks (14 days). That is one cycle. 

This is repeated for as long as your health specialist says. Always follow your health specialist’s directions carefully.

Importance of taking Trifluridine Tipiracil after morning and evening meals: The trifluridine tipiracil may cause a reduction WBCs. Taking this medicine after morning and evening meals may help scale down this effect. This is crucial because a low WBC count can make you a bit more prone to infection. The type of food you consider does not affect trifluridine and tipiracil. Just be sure to take your trifluridine tipiracil doses promptly after or up to 1 hour following meals.

Certain Things to Keep in Mind About Taking Trifluridine Tipiracil:

• In order to procure this medicine, always get in touch with a pharmaceutical wholesaler or supplier or distributor that holds certain authentic certification such as WHO-GDP and ISO. 
• The trifluridine tipiracil price is reasonably very less due to the availability of generic and innovator brands. Generic versions tend to cost less than their innovator alternatives. 
• Store the tableta of trifluridine tipiracil at room temperature between 68°F and 77°F (20°C to 25°C).
• Don’t store this medicinal product with other medicines. Keep it in its own container.
• In case you store your pills outside of the original container, any unused tablets should be disposed of after 30 days.
• Wash your hands once you handle pills. Even though it is a pill, it is still chemotherapy.
• Note that there is a packet inside the bottle that helps absorb moisture. Never swallow this material.

NOTE: Deets mentioned in this article is for informational or educational purposes only, and does not substitute professional medical advice or consultations with health specialists.