Fulvestrant Guidance

Fulvestrant helps in treating hormone receptor (HR)-positive metastatic breast cancer in postmenopausal women with disease progression and HR-positive, HER2-negative advanced breast cancer in combination with palbociclib in women with disease progression after endocrine therapy. Fulvestrant is a selective estrogen receptor degrader (a type of drug which binds to the estrogen receptor). Faslodex is the trade name of Fulvestrant. The strength of the medicine is 250 mg.

Dosage and Administration

Fulvestrant injection is for intramuscular administration. For the proper dosage, the patient should seek a prescription prescribed by the doctor, administer the recommended dose of Fulvestrant 500 mg intramuscularly into the buttocks slowly (1 - 2 minutes per injection) as two 5 ml injections, one in each buttock, on Days 1, 15, 29, and once in a month after that. Fulvestrant 250 mg is also given in combination with other drugs such as palbociclib, abemaciclib, or ribociclib. Administration instructions are as follows: 

1. Remove the glass syringe barrel from the tray and check that it is not damaged.
2. Remove the perforated patient record label from the syringe. 
3. Peel open the safety needle outer packaging. For complete SafetyGlide instructions, refer below to the "Directions for Use of SafetyGlide."
4. Break the white plastic cover seal on the syringe Luer connector to remove the cover with the attached rubber tip cap.
5. Twist to lock the needle to the Luer connector.
6. Remove needle sheath.
7. Remove excess gas from the syringe. 
8. Administer intramuscularly slowly in the buttock. 
9. Immediately activate the needle protection device upon withdrawal from the patient by pushing the lever arm completely forward until the needle tip is fully covered.
10. Visually confirm that the lever arm has fully advanced and the needle tip is covered. If unable to activate, discard immediately into an approved sharps collector. 
11. Repeat steps from 1 to 10 for the second syringe. 

Side Effects  

Fulvestrant 250 mg common side effects are; nausea, injection site reactions, weakness, and elevated transaminases (an indicator of liver dysfunction). Drug's severe side effects are urinary tract infections, hypersensitivity reactions, loss of appetite, headache, blood clots in veins, hot flushes, vomiting, diarrhea, elevated bilirubin, rashes, and intense back pain. 

Precautions

It advises females of reproductive potential of the potential risk to a fetus and uses effective contraception during treatment with inj Fulvestrant and for one year after the last dose. Doctors advise using it with caution in patients with bleeding diathesis, thrombocytopenia, or anticoagulant use. Before taking this medicine, one should go for counseling and run a check-up for medical complications in the future.

Fulvestrant injection price

It is seen that the price of Fulvestrant Injection made by innovators is more costly than the other suppliers. In India, Fulvestrant injection comes at reasonable prices. The drug is readily available with the suppliers like Ikris Pharma Network, a trusted brand for supplying such rare medications in India and abroad ASAP.